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Research

• Core Technologies
  • RNAi Library
  • HT Microscopy
  • Optical Trap
  • Single Molecule Fluorescence
    • Single Molecule Microscopy for Living Cells
    • Single Molecule Molecule Microscopy for Proteins In Vitro
  • Microscopy Software

• Recent Research
  • Mechanism of Motors Proteins
    • Kinesin
      • Kinesin Mechanism
        • Our model for the kinesin mechanism
        • Structural Studies
      • Minus-End-Directed Kinesin
      • Regulation of Kinesins
        • Kinesin 1
        • Kinesin 2 (Kinesin/Osm3)
        • Kinesin 3
    • Dynein
  • Protein complexes that bind plus ends of microtubules
    • Structural Studies
    • Biological Studies
  • Microtubule Severing
    • Spastin
    • Katanin
      • What is Microtubule Severing?
      • How was Severing First Observed?
      • Enter Katanin
      • What Does Microtubule Severing by Katanin Look Like?
      • What Do We Know About the Katanin Subunits?
      • How Does Katanin Work?
      • How Do AAA Proteins Work in General
  • Mitosis, Motors, Microtubule Nucleation
    • Localization and dynamics of mitotic kinesins
    • Mechanisms of spindle pole focusing
    • Control of metaphase spindle length
    • Genome-wide screening of spindle morphology
    • Microtubule Nucleation
    • Mitosis and Kinesin
  • Signal Transduction in T cells- Imaging Approaches
  • Visualizing Stem Cells and Organ Repair in Planarians
  • RNAi Screens
  • Whole Genome RNAi Screen

• Other Projects

• Organelle Transport
  • Reconstituting Organelle Transport Using Dictyostelium discoideum
  • Mechanism of Organelle Transport by Unc104 in Neurons of Living C. elegans
• RNA Transport
  • Yeast
    • Initial Findings
    • Finding New Localized mRNAs through DNA Microarray Technology
    • Identifying Zipcodes from Localized RNA Sequences
    • Creating Separate Plasma Membrane Comparments in Yeast
    • Finding Localization Elements
  • Drosophila
• Actin Binding Proteins

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• Vale Lab Papers 1996 - current
• Vale Lab Papers 1979-1995

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